![]() ![]() Investigations showed that 77% of New Year’s resolvers broke their pledges after one week and only 19% successfully kept them for two years. Unsurprisingly, NdRF levels decrease rapidly. This is associated with terminating any ambitions of dieting as part of the New Year resolutions by mid-January. Here, the Necessity for diet-releasing factor (NdRF) is produced that reaches peak level around 2nd January. In order to restore homeostasis, antagonising mechanisms are activated that stimulate another cluster of neurons in the hypothalamus called the “New Year’s Resolution centre”. Interestingly, significant weight gains have been observed in adults during holiday season in general even when weight loss was aimed for (Díaz-Zavala et al., 2017)! Upregulation of IIC in particular seems to be associated with body weight gain in adults during Christmas season. Three associated genes have been identified: GBF1 ( GINGERBREAD FATTENING 1), MWG ( MULLED WINE GUZZLING) that encodes a novel class III alcohol dehydrogenase, and IIC ( INDULGING IN CHOCOLATE, also known as I’M IN CONTROL-HONESTLY). Thereafter, activity decreases extremely fast and reaches dormancy again at 1st of January.Īctivation of the “Christmas vivifying centre” results in an upregulation of liver enzyme production via the Christmas-stimulating hormone (CSH) in anticipation of extensive feeding. Activity in this centre gradually increases with the beginning of December and shows peak activity at 25th and 26th December. ![]() It is a cluster of neurons that is dormant for 11 months of the year. The Christmas circannual rhythm is generated in a region of the hypothalamus labelled “Christmas vivifying centre”.
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